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Unlike native IGF-1, which requires frequent administration due to its short half-life and extensive IGFBP binding, IGF-1 LR3's enhanced stability and bioavailability make it a more practical candidate for investigating growth factor-mediated tissue regeneration and metabolic regulation

KPV has been studied for its role in supporting immune balance and gut barrier function

The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

Due to the properties above, GHK-Cu is being studied as a supplementary means for post-procedure recovery when performing cosmetic procedures such as micro-needling and laser resurfacing